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Anti-Aging Therapeutics, Vol. 11
Proceedings of the Sixteenth World Congress on Anti-Aging Medicine and Regenerative Biomedical Technologies; Spring, Summer and Winter Sessions.

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The American Academy of Anti-Aging Medicine (A4M) is proud to launch Longevity Magazine¢â. A unique feature of The World Health Network, www.worldhealth.net, the A4M¡¯s educational website, Longevity Magazine¢â e-Journal is an electronic publication that provides timely and informative news relating to wellness, prevention, and biotech advancements in longevity. Our mascot is the Galapagos tortoise (Geochelone nigra). A gentle giant that measures six feet head-to-toe and subsists on plants, the Galapagos tortoise boasts the longest animal lifespan, averaging at 150 years and a maximum lifespan of 300 years.
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Health Headlines
- Dark Chocolate Compound May Protect Brain From
   Stroke Damage
- Short Duration Sleep Linked to Increased Risk of
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- Endometrial Stem Cells Repair Parkinson¡¯s Brain Damage - Triglycerides Increase Risk of Heart Disease - Genetic Predisposition to Type 2 Diabetes Promotes
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Chocolate Functional Foods
Dark Chocolate Compound May Protect Brain From Stroke Damage
A compound found in dark chocolate has been found to protect the brain from ischemic damage by increasing cellular signals that are known to protect neurons from damage. Sylvain Doré, Ph.D., and colleagues at Johns Hopkins University School of Medicine induced an ischemic stroke in two groups of mice, one group of which had been fed a single dose of the flavanol epicatechin.
sleep Sleep
Short Duration Sleep Linked to Increased Risk of Premature Death
A review of 16 prospective studies involving more than 1.3 million participants has revealed that sleeping for less than 6 hours each night significantly increases the risk of premature death. Professor Francesco Cappuccio, leader of the Sleep, Health, and Society Programme at the University of Warwick (UK) and colleagues found that people who sleep for less than six hours each night were 12% more likely to die prematurely than those who get the recommended 6-8 hours.
stem cell Neurology
Endometrial Stem Cells Repair Parkinson¡¯s Brain Damage
Preliminary study results offer hope of a new treatment for women with Parkinson's disease. Professor Hugh S Taylor of Yale School of Medicine and colleagues colleted and cultured endometrial stem cells obtained from 9 women.
Stethoscope Cardio-Vascular
Triglycerides Increase Risk of Heart Disease
Results of a review of data from 101 studies involving more than 350,000 people have linked triglycerides, a type of fat found in the blood, to coronary heart disease. Dr Nadeem Sarwar and colleagues at Cambridge University (UK) based their study on the ?1131T>C (rs662799) promoter polymorphism of the apolipoprotein A5 (APOA5) gene, a genetic variant that is known to increase triglyceride levels.
Waistline Weight and Obesity
Genetic Predisposition to Type 2 Diabetes Promotes Weight Gain
Researchers at the Garvan Institute of Medical Research in Sydney, Australia, have found that healthy people who are genetically predisposed to develop type 2 diabetes are more likely to gain weight than their non-genetically-predisposed peers. Professor Lesley Campbell and colleagues recruited 17 healthy people with a family history of type 2 diabetes and 24 healthy people with no family history of the disease for their 28-day-long study.
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FREE Video Excerpt

Concussions & Sports
with Dr. Joseph C. Maroon, MD
With summer¡¯s arrival, more of us will enjoy outdoor sporting activities. Dr. Robert Goldman, A4M Chairman, interviews Dr. Joseph C. Maroon, A4M's Senior Vice President, and Professor and Vice Chairman of Neurological Surgery at the University of Pittsburgh School of Medicine and the Heindl Scholar in Neuroscience. Dr. Maroon explains his insightful research into concussions and appropriate preventative guidelines for sports activities, which led to his development of the "Impact" system, a neurocognitive computer-based assessment that has become the standard of care for many sports organizations, including the NHL and NFL. Dr Maroon also discusses research into nerve growth and stem cells and their relevance to spinal injuries in the field of sports.
soccer Genetics
Physical Activity in Adolescence Blunts 'Fat' Gene
New research suggests that being physically active during adolescence can help to blunt the effect of a mutation in the 'fat gene' FTO, which predisposes a person to becoming overweight or obese. Research has shown that the rs9939609 mutation of the FTO, or fat mass, gene is associated with a higher rate of body mass, fat, and waist circumference.
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Established in 1992 and comprised of 24,000 member physicians, health practitioners, and scientists representing 110 nations worldwide, The American Academy of Anti-Aging Medicine, Inc. (A4M) is a non-profit medical organization dedicated to the advancement of technology to detect, prevent, and treat aging related disease and to promote research into methods to retard and optimize the human aging process. A4M is also dedicated to educating physicians, scientists, and members of the public on anti-aging issues. A4M believes that the disabilities associated with normal aging are caused by physiological dysfunction which in many cases are ameliorable to medical treatment, such that the human lifespan can be increased, and the quality of one¡¯s life improved as one grows chronologically older. A4M seeks to disseminate information concerning innovative science and research as well as treatment modalities designed to prolong the human lifespan. Although A4M seeks to diss e minate information on many types of medical treatments, it does not promote or endorse any specific treatment nor does it sell or endorse any commercial product .
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Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial
Objectives To study the effects of metformin on the incidence of vitamin B-12 deficiency (<150 pmol/l), low concentrations of vitamin B-12 (150-220 pmol/l), and folate and homocysteine concentrations in patients with type 2 diabetes receiving treatment with insulin.
Design Multicentre randomised placebo controlled trial.

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Safety and Efficacy of the Herbal Drug Hypericum Perforatum for the Treatment of Premature Ejaculation
ABSTRACT - INTRODUCTION: Premature ejaculation (PE) is one of the most prevalent forms of male sexual dysfunction. The benefits of Hypericum perforatum for treatment of PE are unknown, although it is hypothesized that its effect on depression and neurotransmitter activity may be beneficial. The authors assessed the efficacy and safety of H. perforatum for the treatment of PE.
METHODS: A prospective, double-blind, randomized, placebo-controlled design was used. Participants were 50 married men with PE. They were 18-50 years old and were evaluated between January 2007 and December 2008. Patients were randomly assigned to one of 2 equal groups. Group 1 received 3 daily tablets of hypericum extract (150 mg per tablet). Each tablet contained 160µg of hypericin. Group 2 received a placebo. All participants recorded intravaginal ejaculation latency time (IELT) and completed the International Index of Erectile Function (IIEF-5) questionnaire before and after treatment. Side effects were self-reported using a questionnaire. Results were compared using chi-square and paired t tests.
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The Chicago Blackhawks are the First Vitamin D Team in Modern Professional Sports History
The Chicago Blackhawk team physicians began diagnosing and treating vitamin D deficiency in all Blackhawk players about 18 months ago. Apparently, most players are on 5,000 IU of vitamin D3 per day. To confirm this assertion, simply ask the Blackhawk organization.

After many losing seasons, last year the Blackhawks came out of nowhere to get to the Western conference finals. This year the Blackhawks are playing even better.
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Maternal Vitamin A Supplementation and Lung Function in Offspring
ABSTRACT: Background Vitamin A is important in regulating early lung development and alveolar formation. Maternal vitamin A status may be an important determinant of embryonic alveolar formation, and vitamin A deficiency in a mother during pregnancy could have lasting adverse effects on the lung health of her offspring. We tested this hypothesis by examining the long-term effects of supplementation with vitamin A or beta carotene in women before, during, and after pregnancy on the lung function of their offspring, in a population with chronic vitamin A deficiency.
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Docosahexaenoic acid induces proteasome-dependent degradation of estrogen receptor a and inhibits the downstream signaling target in MCF-7 breast cancer cells
Abstract: About two thirds of breast cancers in women are hormone-dependent and require estrogen for growth, its effects being mainly mediated through estrogen receptor a (ERa). Docosahexaenoic acid (DHA, 22:6n-3) and arachidonic acid (AA, 20:4n-6) have opposite effects on carcinogenesis, with DHA suppressing and AA promoting tumor growth both in vitro and in vivo. However, the mechanism is not clear. Here, we examined whether the effect is mediated through changes in ERa distribution. MCF-7 cells, an ERa-positive human breast cancer cell line, was cultured in estrogen-free medium containing 0, 10 or 60 µM DHA or AA, then were stimulated with estradiol.
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