비만, 노화방지
피부미용, 성형
탈모(모발이식) 연구회

표피노화방지에서 AMP의 역활

요즘 환자도 많이 줄고 좀 느슨해지는거 같습니다. 차라리 이럴때 일수록 공부를 좀 해야겠다는 생각에 여기저기 관련 저널을 찾아보고 있는데 괜찮다고 생각하는 것들은 여기에 올려놓을 생각입니다.

선생님들도  여력이 되신다면 같이 올려보시는것은 어떨가요!

아래 내용은 표피에서의 노화과정을 설명해 주는 부분이 있어서 도움이 될거 같습니다.

Effects of adenosine 5'-monophosphate on epidermal turnover.

Department of Dermatology, Wakayama Medical University, Wakayama, Japan.

The structure and function of the epidermis is maintained by cell renewal based on epidermal turnover. Epidermal turnover is delayed by aging, and it is thought that the delay of the epidermal turnover is a cause of aging alternation of skin. The epidermal turnover is related to the energy metabolism of epidermal basal cells. Adenosine 5'-triphosphate (ATP) is needed for cell renewal: cell division, and adenosine 5'-monophosphate (AMP) increases the amount of intracellular ATP. These findings suggest that AMP accelerates the epidermal turnover delayed by aging. This study investigated whether AMP and adenosine 5'-monophosphate disodium salt (AMP2Na) accelerates the epidermal turnover. An effect of AMP2Na on cell proliferation was examined by our counting of keratinocytes. An effect of AMP2Na on cell cycle was examined by our counting of basal cells in DNA synthetic period of hairless rats. The effects of AMP2Na (or AMP) on the epidermal turnover were examined by our measuring stratum corneum transit time by use of guinea pigs, and by our measuring stratum corneum surface area by use of hairless rats and in a clinical pharmacological study. The AMP2Na showed two different profiles on the proliferation of primary cultured keratinocytes. At a low concentration it induced cell growth, whereas at a high concentration it inhibited cell growth. The number of basal cells in the DNA synthetic period of AMP2Na was significantly higher than that of the vehicle in hairless rats. The stratum corneum transit time of AMP2Na was significantly shorter than that of the vehicle in guinea pigs. The corneocyte surface area of emulsion containing AMP2Na was significantly smaller than that of the vehicle in volunteers. We conclude that AMP promotes the cell proliferation and the cell cycle progression of epidermal basal cells and accelerates epidermal turnover safely. In addition, AMP is useful for skin rejuvenation in dermatology and aesthetic dermatology.

PMID: 18758798 [PubMed - in process]


by 윤석찬  at  2008.11.07. 10:42

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